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At the heart of organic chemistry is the effective synthesis of
natural products or compounds, which are important for
pharmaceuticals and agrochemicals, for example. These syntheses
often include new reactions and novel concepts in organic
chemistry, such that there is always a need for innovative
strategies and improved methods.
This textbook presents not only synthetic ways to design organic
compounds, it also contains a compilation of total synthesis with a
comparative view of multiple designs for the same targets. It
explains different tactics and strategies, making it easy to apply
to many problems, whatever the synthetic question in hand.
Following a historical view of the evolution of synthesis, the book
goes on to look at principles and issues impacting synthesis and
design as well as principles and issues of methods. The sections on
comparative design cover classics in terpenes and alkaloid
synthesis, while a further section covers such miscellaneous
syntheses as Maytansine, Palytoxin, Brevetoxin B and Indinavir. The
whole is rounded off with a look at future perspectives.
With its attractive layout highlighting key parts and tactics
using a second color this is a useful tool for organic chemists,
lecturers and students in chemistry, as well as those working in
the chemical industry.
A native of North Carolina, Josephine Reed was educated at the
University of North Carolina at Greensboro (B.A., English),
Appalachian State University (B.A., biology and chemistry), and
Virginia Tech (Ph.D., chemistry). Besides her many, many years as a
student, she has spent time as a department store clerk, a
waitress, a banker, a bartender, and a chemistry instructor.
Shecontinues her eclectic career at Brock University in St.
Catharines, Ontario, where she shares her life and her work with
the co-author and their son. Still an English major at heart, Josie
has always had a secret desire to be a writer, preferably a poet,
and is delighted to be a part of the making of this book.
Tomas Hudlicky was born and raised in Prague, Czechoslovakia and
emigrated to the US in 1968. He received his PhD in 1977 under the
direction of Professor Ernest Wenkert in the field of indole
alkaloid total synthesis. He then spent a year at the University of
Geneva working under the late Professor Wolfgang Oppolzer on the
synthesis of isocomene. He began his academic career in 1978 at the
Illinois Institute of Technology and moved to Virginia tech (1982)
and to the University of Florida(1995). In 2003, he accepted an
offer from Brock University where he currently holds the position
of Canada Research Chair professor of Organic synthesis and
Biocatalysis. His current research interests include the
development of enantioselective synthetic methods, bacterial
dioxygenase-mediated degradation of aromatics and isolation of
chiral metabolites for use in asymmetric synthesis, design and
synthesis of fluorinated inhalation anesthetic agents, synthesis of
morphine and Amaryllidaceae alkaloids, organic electrochemistry,
and design of unnatural oligo-saccharide conjugates and polymers
with new molecular properties. His hobbies include martial arts,
music, hockey, and skiing and he enjoys all of these with his 17
year old son Jason.
This two-colored textbook presents not only synthetic ways to
design organic compounds, it also contains a compilation of the
most important total synthesis of the last 50 years with a
comparative view of multiple designs for the same targets. It
explains different tactics and strategies, making it easy to apply
to many problems, regardless of the synthetic question in hand.
Following a historical view of the evolution of synthesis, the book
goes on to look at principles and issues impacting synthesis and
design as well as principles and issues of methods. The sections on
comparative design cover classics in terpenes and alkaloid
synthesis, while a further section covers such miscellaneous
syntheses as Maytansine, Palytoxin, Brevetoxin B and Indinavir. The
whole is rounded off with a look at future perspectives and, what
makes this textbook extraordinairy, with personal recollections of
the chemists, who synthesized these fascinating compounds.
With its attractive layout highlighting key parts and tactics using
a second color, this is a useful tool for organic chemists,
lecturers and students in chemistry, as well as those working in
the chemical industry.
"I think, as will many organic chemists, that the Hudlicky book
will be the Bible of synthetic organic chemistry, the past, the
present and the future. A hallmark publication." (Victor Snieckus)
This fourth volume in the series "Organic Synthesis: Theory and
Applications" is composed of five chapters that span a wide range
of disciplines. Alkaloid chemistry, total synthesis, synthetic
methodology, carbohydrate technology, and spin-trapping agents are
all covered by experts in these fields.
The first chapter is one of the finest examples of deductive
reasoning in the chemical literature, examining the rich history of
the chemistry of morphine. Within the following chapters, synthetic
challenges of the marine terpenoids are brought into focus, the
chemistry and synthetic applications of cyclobutenediones are
reviewed and the utility of glycosyl iodides in the preparation of
glycosides are summarized. Finally a report on a new class of
spin-traping agents, azulenyl nitrones is covered. In all, five
diverse subdisciplines are brought together and reviewed in this
volume.
Part of a series which covers areas of organic synthesis ranging
from the latest developments in enantioselective methodologies, to
reviews of updated chemical methods. The volumes are written by
experts, who describe their own area of expertise, as well as those
of their peers.
Volume 5 in this series spans a variety of topics including terpene
synthesis, amino acid synthesis, and combinatorial methods for
generation of structural diversity.
The first chapter has been contributed by Trond Hansen and
Professor Yngve Strenstrom of the Agricultural University of
Norway, and surveys naturally occurring cyclobutanes. As well as
providing a review of representative syntheses and synthetic
strategies for the introduction of cyclobutane into target
molecules, the number of rings contained in the natural product is
also discussed in logical order.
The following chapter, written by Professor Timothy Brocksom, his
wife Ursula, and a number of co-workers from the Federal University
of Sao Carlos, surveys the synthesis of higher terpenes by the use
of Diels-Alder reaction. A useful review of the current literature
in this field is provided, together with 79 references and
footnotes.
The third chapter, written by Michael G. Natchus and Xinrong Tian
of Procter & Gamble Pharmaceuticals, covers recent advances in
the synthesis of unnatural amino acids. Three of the major
asymmetric methods are discussed and grouped according to the
chemistry involved.
The fourth and final chapter has been contributed by Professor
Dennis Wright of the University of Florida, and other co-workers. A
review of the combinatorial chemistry methods currently available
for lead discovery in pharmaceutical research is provided in this
chapter, as well as discussions on the methods based on natural
products and an overview of the complexity building
techniques.
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